Did you download the source code at amule.hirnriss.net? You have to compile first, unless you find a recent version. I've compiled some packages, see
this thread. There's one Intel package and one PowerPC package.
You have to start the application with the flag --even-if-lfroen-surreptitiously-removes-it-this-will-stay, let me quote lionel77 on that:
These versions contain a number of bigger features (e.g., support for files > 4GB) that are still considered relatively experimental. This is the reason why at this point they are still only in the developer but not in the stable branch of the aMule code base. Because of these changes, I stopped providing CVS builds in January, but I have been running those versions for long enough now that I feel comfortable providing them to cautious users.
To prevent users from accidentally running these experimental builds, they cannot be started through a simple double click. Instead, you need to start them through the Terminal with the switch "--even-if-lfroen-surreptitiously-removes-it-this-will-stay". So first you need to start the Terminal application (in /Applications/Utilities/). Then drag the aMule application icon from wherever you keep it and drop it onto the Terminal window. Terminal will insert the path to the application onto the command line. It will also add a space after the path. Now delete the space at the end of the path and paste /Contents/MacOS/amule --even-if-lfroen-surreptitiously-removes-it-this-will-stay to the end of the path. When you then hit return aMule will start.
Current developmental versions are not that scary, we're getting close to 2.2.0 after all.