In simple term NO. As in general our P2P ED2K(2G)/KAD(3G) clients are mostly ~Mule and time to time you will see mldoney, lphant. So if you don't have access to the gateway to manually setup standard full cone static NAT/PAT table then your out of luck as it doesn't support NAT-T and IPv6 as well. As these client's don't utilize anything other than basic UPnP/NAT-PMP support if enabled by the gateway.
Edit: link removed