same problem here, since update to 10.4.8 everything slowed down, safari, mail, all other programs, wlan connection brakes sometimes..
i tried to restart macos, but same problem..
when opening amule the symbol is "bouncing" for a few minutes when finaly the amule window is opened behind all other windows, when trying to get it to the front the symbol for "working" this funny wheel or whatever, appears.. unable to get to the preferences or to close is the normal way..
also when forcing closing it needs a few tries to close it..
desperate

stats: macos 10.4.8 on an intel 1,83 imac with 1,5gigs of ram
EDIT:
and please maybe when the developers release a new version of amule PLEASE integrate an automatic installer!!!
thank you