Unfortunately I cannot say a lot about the problem. I does not work with wxGTK without debug (there's no change when loading a skin) and with debug enabled there were the backtraces as they are seen in the attachment.
I haven't figured out what is wrong, one skin was sometimes working, but not every time I tried to set it, none of the others.
Happened with Ubuntu 6.10, wxGTK 2.8.0 yesterday's CVS.
I did a fresh a install on a newly set up Arch Linux machine with wxGTK 2.8.0 and today's CVS and wasn't abled to enable any skins either.
Is there someone out there using skins with recent CVS without having problems?
What system do you use? (wx, amule-versions)