Well, I suspect I'm facing the same performance issue described in this thread. The thing is, it appears that GUI commands are MUCH slower in 2.1.0 than in 2.0.3. Whenever I'm running some CPU-intensive process, aMule is essentially unresposive to clicking. This applies to most clicking, from clicking on a tab, switiching to the tab, focus switching from/to amule window, maximizing/minimizing amule window, writing in the search form... 2.0.3 performs reasonably well! Renice doesn't help, but to be fair, it might be something related to resource allocation, 'cause while aMule 2.0.3 uses its fair bit of resources (checked via "top"ing from the terminal), 2.1.0 doesn't!
HTH - Mattia