This wedges on me reliably, often at startup but always within a couple of hours.
2.1.3 at least could usually run for several days. 10.5.5, G5
My English is not so good,
at startup or after a couple of hours amule crashes? Or became slow?
On Tiger I runned monolitich aMule for several hours and daemon for at least 15 days without problems.
Have you tried to delete old preferences?
Have you old version of aMule in your HDs? If yes, try to delete they (chmod 000 is ok).
Can you try to launch aMule from Terminal and post output and log?
Applications -> Utilities -> Terminal:
$ /Applications/aMule.app/Contents/MacOS/amule
Try debug version from here:
http://forum.amule.org/index.php?topic=13920.0and follow this:
http://www.amule.org/wiki/index.php/BacktracesI suggest you to try the daemon.
EDIT:
If you have CPU-intensive applications like boinc or xgrid amule seems to hang,
really it works but very very slow.