Kad info and ED2K info are now duplicated in those screenshots. Unless anyone has a good idea about what to do with the sole two log tabs left after removing those for duplication, it's a no-no change.
Kad window: all the bootstrap/node options should be together, not have the info between them.
Server window: What the hell is Disconnect doing there? Also, the server list is a list, with plenty of columns people might want to see, and restricting the horizontal space for it is not a good idea (all IMHO) specially if it leaves a giant blank space because we can't even fit enough information in the right side.
Both Kad and server window: The URL fields are now too small to see the whole URL. This is a regression, especially with no scrollbars, because now to see the content of the url I ahve to move along it with the keyboard or slowly select it with the mouse.
Statistics window: I am torn in this one. I like the parts of the information that are more visual (graphs) to be predominant, and now the statistics graphs are too small in my opinion. OTOH, the statistics tree is bigger, and this not only adds readability to it but also will reduce CPU load from redrawing the graphics (as they are smaller now). The tree is a vertical item, so it taking a whole vertical space makes sense.
A different approach to the statistics window is adding a new "custom" graph that contains statistics of items selected from the tree, and that way having not only a whole vertical space for the tree, albeit smaller than yours, but also a new graph that cna show very useful information for the user (or just curiosities). This of course could be a implementation nightmare.
And remember: We're not an eMule clone.