I recently tracked down packet loss present when aMule was running on my Linux file server/firewall (full PC with Debian, not an appliance). The only parameter that had a real effect was the "maximum number of connections per 5 seconds" under advanced settings. Unfortunately it only goes down to 5, at which setting I still have about 1% loss. Loss with 10 is about 5%. I am pretty sure the loss happens within the cable modem, which may have a not too well done Firmware, but unfortunately I cannot do anything about this.
So while I found a way to reduce loss (all other parameters have basically no effect), there seems to be a lower Limit on this to the effect that you cannot have less than 5 new connections per 5 seconds. Please remove this limit, there is already ample warning on the configuration page in amulegui and I would rather be able to eliminate the loss and have worse performance than better performance but occasional real network issues.