it might not be the case, but just as a side note:
whenever "amule stopped responding to mouse inputs" happens, make sure no aMule windows (such as the Preferences window, some alert window, the About window, a notice window, warning window... whatever window) are hidden _behind_ aMule or anywere. aMule waits for such windows to be closed. Untill then, aMule's main window keeps unresponsive.
As I said, just as a side note. It might not be the case ;-)
Greetings fctk! :-)