yes, wxgtk 2.5.3 is better than other 2.5.x releases.. it fixes i.e broken search in amule when wxgtk was linked against gtk2..
what rpms do u need, suse or other?
and compilation.. still memleaks with gtk2, so better to use it linked against gtk1 ..
use ./configure --prefix=/usr --disable-gtk2 --with-gtk
but remove all previous wxgtk versions first
cheers