I just went through aMule's default settings and here are some suggestions on how to change them:
[x] Prompt on exit
Since queue positions etc. are lost when quitting aMule accidentally I would enable this option.
[ ] Update serverlist when connecting to a server
[ ] Update serverlist when a client connect(s)
These days, most servers you get through these options are fake servers, so I would just turn them off.
[x] Safe connect
I'm not so sure on this one, but it seems like this would be a good option to enable.
[x] Save 10 sources on rare files
This one we should definitively enable in my opinion.
[ ] Auto-update ipfilter at startup
We don't provide a default url, so I am not sure why we have this enabled.
[ ] Show fast ED2K Links handler
I think we should turn this off. Having the ed2k links handler on the search page should be enough. It just steals a lot of space on the other pages.
Finally, I'd like to suggest that aMule automatically downloads a server.met when the current list is empty, so that new users don't have to press the server.met download button manually.