I experienced the same problem too.
Once ,i had amule 2.0 rc5 running for more than 3 weeks and well, it didnt crash, but i had to close it and restart it since it wouldnt download at more than 2 or 3 kbps ;( .
It was an incremental decrease in download speed, eveyday was a bit slower than the day before. In fact the whole (i.e. program interface) program was slow, right clicking and waiting forever to see the menu, clicking on another tab and wait long times to change... so i guess the problem resides in that amule eats more and more system resources as time goes by and it gets to a time when its got not enough power left for calculations, opening and closing conections, etc...
The upload speed was always constant though. at around 9kbps as it is set, so no problem there.